RP16

Effect of the colonisation by selected commensal bacteria on the host immune response

For this research project, Mrs Emelyne LECUYER has been recruited.

Main supervisor

INSERM U793 - INRA (V. Gaboriau & N. Cerf-Bensussan)

Co-supervisor

University of Debrecen (E. Rajnavolgyi)

Duration : 36 months 

Type of recruitment: This PhD project will be financed by INRA, no eligibility rules but a master degree in Immunology will be an asset.

Start date : end of 2008/beginning of 2009

Objective. The project is to investigate the role of commensal bacteria in inducing and shaping post-natal maturation of adaptive cell immune responses, and will take advantage of the use of gnotobiotic mouse models.

Techniques that will be used. Studies will combine in vivo and ex vivo approaches, and rely on basic techniques of microbiology and on a large panel of cellular immunology techniques (isolation of lymphocytes subsets, multicolor flow cytometry, ELISA, BioPlex, ELISPOT, quantitative RT-PCR, confocal microscopy). Complementary approaches in microbiology and biochemistry will be developed when needed in collaboration with Cross-Talk partners.